The positive predictive value of MOG-IgG testing based on the 2023 diagnostic criteria for MOGAD.

ABSTRACT:

Background

Myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) is a relatively new disease entity in the field of demyelinating disorders. Its first diagnostic criteria have recently been published.

Objectives

We evaluated the positive predictive value (PPV) for MOG-IgG testing and report the clinical and radiologic features with respect to the recently published criteria.

Methods

A retrospective study was conducted at three centers in Dallas, Texas. Patients with positive MOG-IgG testing on cell-based assays at any time were included. Positive cases were reviewed by at least two neuroimmunologists for fulfillment of the criteria.

Results

We included 235 patients. The PPV of seropositivity at any time was 78.3% overall, 52.6% for low titer,

SUBMITTER: Nguyen L 

PROVIDER: S-EPMC11325327 | biostudies-literature | 2024 Jul-Sep

REPOSITORIES: biostudies-literature