Vitamin D status and VDR gene polymorphisms in patients with growth hormone deficiency: A case control Tunisian study.

ABSTRACT:

Introduction

Growth Hormone Deficiency (GHD) is a rare disease marked by a complete or partial reduction in the production of growth hormone. Vitamin D deficiency is frequent and may be associated with several pathologies. However, the association between GHD and vitamin D deficiency has not been extensively studied. This study aimed to analyse VDR gene polymorphisms related to vitamin D status to ensure better care for patients with GHD.

Material and methods

A case-control study was conducted at the Children's Hospital of Tunis in collaboration with the Farhat Hached's Hospital of Sousse, including patients with GHD and healthy subjects. Genetic analysis of the VDR gene polymorphisms was performed using PCR-RFLP technique. Haplotypes were examined with Haploview software, w

SUBMITTER: Tombari S 

PROVIDER: S-EPMC11325357 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature