Resting-state functional connectivity of amygdala subregions across different symptom subtypes of obsessive-compulsive disorder patients.

ABSTRACT:

Aim

Obsessive-compulsive disorder (OCD) is a heterogeneous condition characterized by distinct symptom subtypes, each with varying pathophysiologies and treatment responses. Recent research has highlighted the role of the amygdala, a brain region that is central to emotion processing, in these variations. However, the role of amygdala subregions with distinct functions has not yet been fully elucidated. In this study, we aimed to clarify the biological mechanisms underlying OCD subtype heterogeneity by investigating the functional connectivity (FC) of amygdala subregions across distinct OCD symptom subtypes.

Methods

Resting-state functional magnetic resonance images were obtained from 107 medication-free OCD patients and 110 healthy controls (HCs). Using centromedial, basola

SUBMITTER: Kwon H 

PROVIDER: S-EPMC11325364 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature