Highly Specific Voltammetric Detection of Cephalexin in Tablet Formulations and Human Urine Samples Using a Poly(2,4,6-2',4',6'-hexanitrodiphenylamine)-Modified Glassy Carbon Electrode.

ABSTRACT: β-Lactam antibiotics are employed to treat bacterial illnesses. Despite a high level of clinical success, they have encountered serious resistance that demands a high-dose regimen and a new pharmacokinetic combination. This requires continuous monitoring of their levels in pharmaceutical and biological samples. In this study, an electrochemical sensor was developed for the determination of cephalexin (CLN) in pharmaceutical formulations and biological fluid samples. The sensors were developed by modifying a glassy carbon electrode (GCE) using a conducting polymer (dipicrylamine) by potentiodynamic electropolymerization. Characterization (using cyclic voltammetry and electron impedance spectroscopy) results revealed modification of the electrode surface, leading to an enhanced effective ele

SUBMITTER: Kassa A 

PROVIDER: S-EPMC11325428 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature