Evidence for ~12-h ultradian gene programs in humans.

ABSTRACT: Mice and many marine organisms exhibit ~12-h ultradian rhythms, however, direct evidence of ~12-h ultradian rhythms in humans is lacking. Here, we performed prospective, temporal transcriptome profiling of peripheral white blood cells from three healthy humans. All three participants independently exhibited robust ~12-h transcriptional rhythms in molecular programs involved in RNA and protein metabolism, with strong homology to circatidal gene programs previously identified in Cnidarian marine species.

SUBMITTER: Zhu B 

PROVIDER: S-EPMC11325440 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature