Effects of strategic white matter hyperintensities of cholinergic pathways on basal forebrain volume in patients with amyloid-negative neurocognitive disorders.

ABSTRACT:

Background

The cholinergic neurotransmitter system is crucial to cognitive function, with the basal forebrain (BF) being particularly susceptible to Alzheimer's disease (AD) pathology. However, the interaction of white matter hyperintensities (WMH) in cholinergic pathways and BF atrophy without amyloid pathology remains poorly understood.

Methods

We enrolled patients who underwent neuropsychological tests, magnetic resonance imaging, and ¹⁸F-florbetaben positron emission tomography due to cognitive impairment at the teaching university hospital from 2015 to 2022. Among these, we selected patients with negative amyloid scans and additionally excluded those with Parkinson's dementia that may be accompanied by BF atrophy. The WMH burden of cholinergic pathways was qu

SUBMITTER: Kim YE 

PROVIDER: S-EPMC11325579 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature