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Site-Selective Nitration of Aryl Germanes at Room Temperature.

ABSTRACT: We report a site-selective ipso-nitration of aryl germanes in the presence of boronic esters, silanes, halogens, and additional functionalities. The protocol is characterized by operational simplicity, proceeds at room temperature, and is enabled by [Ru(bpy)₃](PF₆)₂/blue light photocatalysis. Owing to the exquisite robustness of the [Ge] functionality, nitrations of alternative functional handles in the presence of the germane are also feasible, as showcased herein.

SUBMITTER: Dahiya A

PROVIDER: S-EPMC11325643 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Site-Selective Nitration of Aryl Germanes at Room Temperature.

Dahiya Amit A Gevondian Avetik G AG Selmani Aymane A Schoenebeck Franziska F

Organic letters 20230926 39

We report a site-selective ipso-nitration of aryl germanes in the presence of boronic esters, silanes, halogens, and additional functionalities. The protocol is characterized by operational simplicity, proceeds at room temperature, and is enabled by [Ru(bpy)3](PF6)2/blue light photocatalysis. Owing to the exquisite robustness of the [Ge] functionality, nitrations of alternative functional handles in the presence of the germane are also feasible, as showcas ...[more]

PMID: 37751597

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