Disulfidptosis signature predicts immune microenvironment and prognosis of gastric cancer.

ABSTRACT:

Background

Disulfidptosis is a newly identified mechanism of cell death triggered by disulfide stress. Thus, gaining a comprehensive understanding of the disulfidptosis signature present in gastric cancer (GC) could greatly enhance the development of personalized treatment strategies for this disease.

Methods

We employed consensus clustering to identify various subtypes of disulfidptosis and examined the distinct tumor microenvironment (TME) associated with each subtype. The Disulfidptosis (Dis) score was used to quantify the subtype of disulfidptosis in each patient. Subsequently, we assessed the predictive value of Dis score in terms of GC prognosis and immune efficacy. Finally, we conducted in vitro experiments to explore the impact of Collagen X (COL10A1) on the progress

SUBMITTER: Liu Z 

PROVIDER: S-EPMC11325698 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature