Targeted gene sequencing reveals disparate genomic mutations between young and older adults in renal cell carcinoma.

ABSTRACT:

Background

Renal cell carcinoma (RCC) is a type of cancer that can develop at any point in adulthood, spanning the range of age-related changes that occur in the body. However, the specific molecular mechanisms underlying the connections between age and genetic mutations in RCC have not been extensively investigated.

Methods

Clinical and genetic data from patients diagnosed with RCC were collected from two prominent medical centers in China as well as the TCGA dataset. The patients were categorized into two groups based on their prognosticated age: young adults (YAs) and older adults (OAs). Univariate and multivariate analysis were employed to evaluate the relationships between age and genetic mutations. Furthermore, a mediation analysis was conducted to assess the associati

SUBMITTER: Zhang B 

PROVIDER: S-EPMC11325735 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature