Bubbling insights: unveiling the true sophorolipid biosynthetic pathway by Starmerella bombicola.

ABSTRACT:

Background

The yeast Starmerella bombicola is renowned for its highly efficient sophorolipid production, reaching titers and productivities of (over) 200 g/L and 2 g/(L h), respectively. This inherent efficiency has led to the commercialization of sophorolipids. While the sophorolipid biosynthetic pathway has been elucidated a few years ago, in this study, it is revisited and true key intermediates are revealed.

Results

Recently, Starmerella bombicola strains developed and evaluated in the past were reevaluated unveiling unexpected findings. The AT enzyme encoded in the sophorolipid biosynthetic gene cluster is the only described enzyme known to acetylate sophorolipids, while the SBLE enzyme encoded by the SBLE gene is described to catalyze the conversion of (acetylated) aci

SUBMITTER: Roelants SLKW 

PROVIDER: S-EPMC11325757 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature