Integrative Population and Physiological Genomics Reveals Mechanisms of Adaptation in Killifish.

ABSTRACT: Adaptive divergence between marine and freshwater (FW) environments is important in generating phyletic diversity within fishes, but the genetic basis of this process remains poorly understood. Genome selection scans can identify adaptive loci, but incomplete knowledge of genotype-phenotype connections makes interpreting their significance difficult. In contrast, association mapping (genome-wide association mapping [GWAS], random forest [RF] analyses) links genotype to phenotype, but offer limited insight into the evolutionary forces shaping variation. Here, we combined GWAS, RF, and selection scans to identify loci important in adaptation to FW environments. We utilized FW-native and brackish water (BW)-native populations of Atlantic killifish (Fundulus heteroclitus) as well as a naturall

SUBMITTER: Brennan RS 

PROVIDER: S-EPMC11325861 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature