Glucagon Receptor Antagonist for Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

Heart failure with preserved ejection fraction (HFpEF) is an emerging major unmet need and one of the most significant clinic challenges in cardiology. The pathogenesis of HFpEF is associated with multiple risk factors. Hypertension and metabolic disorders associated with obesity are the 2 most prominent comorbidities observed in patients with HFpEF. Although hypertension-induced mechanical overload has long been recognized as a potent contributor to heart failure with reduced ejection fraction, the synergistic interaction between mechanical overload and metabolic disorders in the pathogenesis of HFpEF remains poorly characterized.

Method

We investigated the functional outcome and the underlying mechanisms from concurrent mechanic and metabolic stresses in the hea

SUBMITTER: Gao C 

PROVIDER: S-EPMC11325917 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature