A correlative study of the genomic underpinning of virulence traits and drug tolerance of Candida auris.

ABSTRACT: Candida auris is an opportunistic fungal pathogen with high mortality rates which presents a clear threat to public health. The risk of C. auris infection is high because it can colonize the body, resist antifungal treatment, and evade the immune system. The genetic mechanisms for these traits are not well known. Identifying them could lead to new targets for new treatments. To this end, we present an analysis of the genetics and gene expression patterns of C. auris carbon metabolism, drug resistance, and macrophage interaction. We chose to study two C. auris isolates simultaneously, one drug sensitive (B11220 from Clade II) and one drug resistant (B11221 from Clade III). Comparing the genomes, we confirm the previously reported finding that B11220 was missing a

SUBMITTER: Yang B 

PROVIDER: S-EPMC11326119 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature