Generative AI for Cell Type-Specific Fluorescence Image Generation of hPSC-derived Cardiac Organoid.

ABSTRACT: Human pluripotent stem cell (hPSC)-derived cardiac organoid is the most recent three-dimensional tissue structure that mimics the structure and functionality of the human heart and plays a pivotal role in modeling heart development and disease. The hPSC-derived cardiac organoids are commonly characterized by bright-field microscopic imaging for tracking daily organoid differentiation and morphology formation. Although the brightfield microscope provides essential information about hPSC-derived cardiac organoids, such as morphology, size, and general structure, it does not extend our understanding of cardiac organoids on cell type-specific distribution and structure. Then, fluorescence microscopic imaging is required to identify the specific cardiovascular cell types in the hPSC-derived car

SUBMITTER: Kandula AKR 

PROVIDER: S-EPMC11326121 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature