Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility.

ABSTRACT: Intrinsic sensory neurons are an essential part of the enteric nervous system (ENS) and play a crucial role in gastrointestinal tract motility and digestion. Neuronal subtypes in the ENS have been distinguished by their electrophysiological properties, morphology, and expression of characteristic markers, notably neurotransmitters and neuropeptides. Here we investigated synaptic cell adhesion molecules as novel cell type markers in the ENS. Our work identifies two Type II classic cadherins, Cdh6 and Cdh8, specific to sensory neurons in the mouse colon. We show that Cdh6+ neurons demonstrate all other distinguishing classifications of enteric sensory neurons including marker expression of Calcb and Nmu, Dogiel type II morphology and AH-type electrophysiolo

SUBMITTER: Gomez-Frittelli J 

PROVIDER: S-EPMC11326146 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature