Paradoxical SERCA dysregulation contributes to atrial fibrillation in a model of diet-induced obesity.

ABSTRACT: Obesity is a major risk factor for atrial fibrillation (AF) the most common serious cardiac arrhythmia, but the molecular mechanisms underlying diet-induced AF remain unclear. In this study, we subjected mice to a chronic high-fat diet and acute sympathetic activation ('two-hit' model) to study the mechanisms by which diet-induced obesity promotes AF. Surface electrocardiography revealed that diet-induced obesity and sympathetic activation synergize during intracardiac tachypacing to induce AF. At the cellular level, diet-induced obesity and acute adrenergic stimulation facilitate the formation of delayed afterdepolarizations in atrial myocytes, implicating altered Ca²⁺ dynamics as the underlying cause of AF. We found that diet-induced obesity does not alter the expression of ma

SUBMITTER: Ponce-Balbuena D 

PROVIDER: S-EPMC11326153 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature