Pregnancy Reduces Il33+ Hybrid Progenitor Accumulation in the Aged Mammary Gland.

ABSTRACT: Aging increases breast cancer risk while an early first pregnancy reduces a woman's life-long risk. Several studies have explored the effect of either aging or pregnancy on mammary epithelial cells (MECs), but the combined effect of both remains unclear. Here, we interrogate the functional and transcriptomic changes at single cell resolution in the mammary gland of aged nulliparous and parous mice to discover that pregnancy normalizes age-related imbalances in lineage composition, while also inducing a differentiated cell state. Importantly, we uncover a minority population of Il33-expressing hybrid MECs with high cellular potency that accumulate in aged nulliparous mice but is significantly reduced in aged parous mice. Functionally, IL33 treatment of basal, but not luminal, epithel

SUBMITTER: Olander A 

PROVIDER: S-EPMC11326159 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature