Aversion-induced drug taking and escape behavior involve similar nucleus accumbens core dopamine signaling signatures.

ABSTRACT: Dopamine release in the nucleus accumbens core (NAcC) has long been associated with the promotion of motivated behavior. However, inhibited dopamine signaling can increase behavior in certain settings, such as during drug self-administration. While aversive environmental stimuli can reduce dopamine, it is unclear whether such stimuli reliably engage this mechanism in different contexts. Here we compared the physiological and behavioral responses to the same aversive stimulus in different designs to determine if there is uniformity in the manner that aversive stimuli are encoded and promote behavior. NAcC dopamine was measured using fiber photometry in male and female rats during cocaine self-administration sessions in which an acutely aversive 90 dB white noise was intermittently presented

SUBMITTER: Grafelman EM 

PROVIDER: S-EPMC11326185 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature