Arsenic impairs <i>Drosophila</i> neural stem cell mitotic progression and sleep behavior in a tauopathy model.

ABSTRACT: Despite established exposure limits, arsenic remains the most significant environmental risk factor detrimental to human health and is associated with carcinogenesis and neurotoxicity. Arsenic compromises neurodevelopment, and it is associated with peripheral neuropathy in adults. Exposure to heavy metals, such as arsenic, may also increase the risk of neurodegenerative disorders. Nevertheless, the molecular mechanisms underlying arsenic-induced neurotoxicity remain poorly understood. Elucidating how arsenic contributes to neurotoxicity may mitigate some of the risks associated with chronic sublethal exposure and inform future interventions. In this study, we examine the effects of arsenic exposure on Drosophila larval neurodevelopment and adult neurologic function. Consistent with

SUBMITTER: Adebambo TH 

PROVIDER: S-EPMC11326188 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature