Prefrontal Cortex subregions provide distinct visual and behavioral feedback modulation to the Primary Visual Cortex.

ABSTRACT: The mammalian Prefrontal Cortex (PFC) has been suggested to modulate sensory information processing across multiple cortical regions via long-range axonal projections. These axonal projections arise from PFC subregions with unique brain-wide connectivity and functional repertoires, which may provide the architecture for modular feedback intended to shape sensory processing. Here, we used axonal tracing, axonal and somatic 2-photon calcium imaging, and chemogenetic manipulations in mice to delineate how projections from the Anterior Cingulate Cortex (ACA) and ventrolateral Orbitofrontal Cortex (ORB) of the PFC modulate sensory processing in the primary Visual Cortex (VISp) across behavioral states. Structurally, we found that ACA and ORB had distinct patterning of projections across cortica

SUBMITTER: Ahrlund-Richter S 

PROVIDER: S-EPMC11326267 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature