YTHDF1 mediates translational control by m6A mRNA methylation in adaptation to environmental challenges.

ABSTRACT: Animals adapt to environmental challenges with long-term changes at the behavioral, circuit, cellular, and synaptic levels which often require new protein synthesis. The discovery of reversible N6-methyladenosine (m⁶A) modifications of mRNA has revealed an important layer of post-transcriptional regulation which affects almost every phase of mRNA metabolism and therefore translational control. Many in vitro and in vivo studies have demonstrated the significant role of m⁶A in cell differentiation and survival, but its role in adult neurons is understudied. We used cell-type specific gene deletion of Mettl14, which encodes one of the subunits of the m⁶A methyltransferase, and Ythdf1, which encodes one of the cytoplasmic m⁶

SUBMITTER: Shi Z 

PROVIDER: S-EPMC11326287 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature