Neural Sequences Underlying Directed Turning in <i>C. elegans</i>.

ABSTRACT: Complex behaviors like navigation rely on sequenced motor outputs that combine to generate effective movement. The brain-wide organization of the circuits that integrate sensory signals to select and execute appropriate motor sequences is not well understood. Here, we characterize the architecture of neural circuits that control C. elegans olfactory navigation. We identify error-correcting turns during navigation and use whole-brain calcium imaging and cell-specific perturbations to determine their neural underpinnings. These turns occur as motor sequences accompanied by neural sequences, in which defined neurons activate in a stereotyped order during each turn. Distinct neurons in this sequence respond to sensory cues, anticipate upcoming turn directions, and drive movement, linkin

SUBMITTER: Kramer TS 

PROVIDER: S-EPMC11326294 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature