Epigenetic heterogeneity shapes the transcriptional landscape of regional microglia.

ABSTRACT: Microglia, the innate immune cells in the central nervous system, exhibit distinct transcriptional profiles across brain regions that are important for facilitating their specialized function. There has been recent interest in identifying the epigenetic modifications associated with these distinct transcriptional profiles, as these may improve our understanding of the underlying mechanisms governing the functional specialization of microglia. One obstacle to achieving this goal is the large number of microglia required to obtain a genome-wide profile for a single histone modification. Given the cellular and regional heterogeneity of the brain, this would require pooling many samples which would impede biological applications that are limited by numbers of available animals. To overcome thi

SUBMITTER: Margetts AV 

PROVIDER: S-EPMC11326298 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature