Altered activity of mPFC pyramidal neurons and parvalbumin-expressing interneurons during social interactions in a <i>Mecp2</i> mouse model for Rett syndrome.

ABSTRACT: Social memory impairments in Mecp2 knockout (KO) mice result from altered neuronal activity in the monosynaptic projection from the ventral hippocampus (vHIP) to the medial prefrontal cortex (mPFC). The hippocampal network is hyperactive in this model for Rett syndrome, and such atypically heightened neuronal activity propagates to the mPFC through this monosynaptic projection, resulting in altered mPFC network activity and social memory deficits. However, the underlying mechanism of cellular dysfunction within this projection between vHIP pyramidal neurons (PYR) and mPFC PYRs and parvalbumin interneurons (PV-IN) resulting in social memory impairments in Mecp2 KO mice has yet to be elucidated. We confirmed social memory (but not sociability) deficits in Mecp2

SUBMITTER: Medeiros D 

PROVIDER: S-EPMC11326302 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature