Alterations of the skeletal muscle nuclear proteome after acute exercise reveals a post-transcriptional influence.

ABSTRACT: Exercise is firmly established as a key contributor to overall well-being and is frequently employed as a therapeutic approach to mitigate various health conditions. One pivotal aspect of the impact of exercise lies in the systemic transcriptional response, which underpins its beneficial adaptations. While extensive research has been devoted to understanding the transcriptional response to exercise, our knowledge of the protein constituents of nuclear processes that accompany gene expression in skeletal muscle remains largely elusive. We hypothesize that alterations in the nuclear proteome following exercise hold vital clues for comprehending the transcriptional regulation and other related nuclear functions. We isolated skeletal muscle nuclei from C57BL/6 mice both sedentary control and o

SUBMITTER: Martin RA 

PROVIDER: S-EPMC11326304 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature