A Strain of Streptococcus mitis Inhibits Biofilm Formation of Caries Pathogens via Abundant Hydrogen Peroxide Production.

ABSTRACT: Commensal oral streptococci that colonize supragingival biofilms deploy mechanisms to combat competitors within their niche. Here, we determined that Streptococcus mitis more effectively inhibited biofilm formation of Streptococcus mutans within a seven species panel. This phenotype was common amongst all assayed isolates of S. mutans , but was specific to a single strain of S. mitis , ATCC 49456. The growth inhibitory factor was not effectively carried in spent supernatants of S. mitis . However, we documented ATCC 49456 to accumulate 4-5 times more hydrogen peroxide (H ₂ O ₂ ) than other species tested, and 5-18 times more than other S. mitis strains assayed. The S. mutans biofilm formation inhibitory phenotype was re

SUBMITTER: Williams I 

PROVIDER: S-EPMC11326308 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature