Educational attainment and mental health conditions: a within-sibship Mendelian randomization study.

ABSTRACT:

Importance

Observational studies have demonstrated consistent protective effects of higher educational attainment (EA) on the risk of suffering mental health conditions (MHC). Determining whether these beneficial effects are causal is challenging given the potential role of dynastic effects and demographic factors (assortative mating and population structure) in this association.

Objective

To evaluate to what extent the relationship between EA and various MHC is independent from dynastic effects and demographic factors.

Design

Within-sibship Mendelian randomization (MR) study.

Setting

One-sample MR analyses included participants' data from the Trøndelag Health Study (HUNT, Norway) and UK Biobank (United Kingdom). For two-sample MR analyses we used summary stati

SUBMITTER: Vinueza Veloz MF 

PROVIDER: S-EPMC11326327 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature