Effects of semaglutide on gut microbiota, cognitive function and inflammation in obese mice.

ABSTRACT:

Objective

This study aims to investigate the effects of semaglutide on gut microbiota, cognitive function, and inflammation in obese mice.

Method

Twenty-four C57BL/6J male mice were randomly assigned to three groups: a normal-chow diet group (NCD, n = 8), high-fat diet group (HFD, n = 8), and HFD+semaglutide group (Sema, n = 8). The mice were fed a HFD to establish an animal model of obesity and then administered with semaglutide or saline for 12 weeks. Cognitive function was assessed using the Morris water maze test. Serum pro-inflammatory cytokines were measured. 16S rRNA gene sequencing technology was used to explore gut microbiota characteristics in obese mice.

Result

Obese mice showed significant cognitive impairment and inflammation. Semaglu

SUBMITTER: Feng J 

PROVIDER: S-EPMC11326427 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature