Determination of the Nanoscale Silica Mass Fraction by AF4/ICP-MS with Isotope Dilution Analysis Using ²⁹Si-Enriched Silica Nanoparticles.

ABSTRACT: A methodology based on the use of asymmetrical flow field-flow fractionation (AF4) coupled to ICP-MS with size fraction-targeted isotope dilution analysis (IDA) has been developed, validated, and applied for the first time to determine the mass fraction of nanoscale silica (SiO₂). For this purpose, ²⁹Si-enriched SiO₂ nanoparticles, to be used as an IDA spike/internal standard, were synthesized and characterized in-house. Double IDA was used to quantify an aqueous suspension of Stöber silica particles of similar characteristics to those of the ²⁹SiO₂ nanoparticle (NP) spike using a representative test material of natural Si isotopic composition as the calibrant. For fumed SiO₂ NP in a highly complex food matrix, a meth

SUBMITTER: Bartczak D 

PROVIDER: S-EPMC11326435 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature