Effect of chronic alcohol consumption on oral microbiota in rats with periodontitis.

ABSTRACT:

Background

The imbalance of oral microbiota can contribute to various oral disorders and potentially impact general health. Chronic alcohol consumption beyond a certain threshold has been implicated in influencing both the onset and progression of periodontitis. However, the mechanism by which chronic alcohol consumption affects periodontitis and its association with changes in the oral microbial community remains unclear.

Objective

This study used 16S rRNA gene amplicon sequencing to examine the dynamic changes in the oral microbial community of rats with periodontitis influenced by chronic alcohol consumption.

Methods

Twenty-four male Wistar rats were randomly allocated to either a periodontitis (P) or periodontitis + alcohol (PA) group. The PA group had unrestricte

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC11326440 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature