Working memory by distributed neural oscillators in a simple nervous system.

ABSTRACT: Working memory allows an animal to gather sensory evidence over time, integrate it with evolving internal needs, and make informed decisions about when and how to act. Simple nervous systems enable careful mechanistic dissection of neuronal microdynamics underlying putative conserved mechanisms of cognitive function. In this study, we show that the nematode C. elegans makes sensory-guided turns while foraging and can maintain a working memory of sensory activation prior to the execution of a turn. This information is integrated with body posture to localize appetitive stimuli. Using a virtual-reality whole-brain imaging and neural perturbation system, we find that this working memory is implemented by the coupled oscillations of two distributed neural motor command complexes. One co

SUBMITTER: Dunn RL 

PROVIDER: S-EPMC11326443 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature