Diminished function of cytotoxic T- and NK- cells in severe alcohol-associated hepatitis.

ABSTRACT:

Aim

Metabolic liver diseases, including alcohol- and non-alcoholic fatty liver diseases (ALD/NAFLD), are characterized by inflammation and decreased ability to prevent infections. Patients with severe alcohol-associated hepatitis (sAH) are particularly susceptible to infections while undergoing treatment with steroids. Understanding the immunological mechanisms for these responses is critical to managing the treatment of patients with metabolic liver diseases. Cytotoxic NK cells and CD8 T cells, using cytolytic granules, serve an important immunological role by killing infected cells, including monocytes. However, patients with sAH have dysfunctional NK cells, which cannot kill target cells, though the mechanism is unknown.

Method

We performed an exploratory study using sing

SUBMITTER: Kim A 

PROVIDER: S-EPMC11326509 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature