RET is a sex-biased regulator of intestinal tumorigenesis.

ABSTRACT: Ret is implicated in colorectal cancer (CRC) as both a proto-oncogene and a tumor suppressor. We asked whether RET signaling regulates tumorigenesis in an Apc-deficient preclinical model of CRC. We observed a sex-biased phenotype: Apc ^Min/+ Ret+/- females had significantly greater tumor burden than Apc ^Min/+Ret+/- males, a phenomenon not seen in Apc ^Min/+ mice, which had equal distributions by sex. Dysfunctional RET signaling was associated with gene expression changes in diverse tumor signaling pathways in tumors and normal-appearing colon. Sex-biased gene expression differences mirroring tumor phenotypes were seen in 26 genes, including the Apc tumor suppressor gene. Ret and T

SUBMITTER: Koester ST 

PROVIDER: S-EPMC11326521 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature