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Identification of novel loci for multiple myeloma when comparing with its precursor condition monoclonal gammopathy of unknown significance.

ABSTRACT:

SUBMITTER: Buradagunta CS

PROVIDER: S-EPMC11326531 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature

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Identification of novel loci for multiple myeloma when comparing with its precursor condition monoclonal gammopathy of unknown significance.

Buradagunta Christopher Staffi CS Arsang-Jang Shahram S Massat Ben B Thapa Bicky B Patek Victoria V D'Souza Anita A Auer Paul P Urrutia Raul R Janz Siegfried S Dhakal Binod B Hari Parameswaran P Dong Jing J

Leukemia 20231102 2

PMID: 37919604

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Coinherited genetics of multiple myeloma and its precursor, monoclonal gammopathy of undetermined significance.

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Project description:Monoclonal gammopathy of undetermined significance (MGUS), a precursor to multiple myeloma (MM), is one of the most common premalignant conditions in the general population. The cause of MGUS is largely unknown. Recent studies show that there is an increased prevalence of MGUS in blood relatives of persons with lymphoproliferative and plasma cell proliferative disorders, suggesting presence of shared underlying genetic influences. In the past few years, additional studies have examined risk factors and biologic characteristics that may contribute to the increased prevalence of MGUS among relatives of probands with MGUS, MM, and other blood malignancies. This article reviews the known epidemiology and risk factors for familial MGUS and myeloma, the risk of lymphoproliferative disorders and other malignancies among blood-relatives of patients with MGUS and MM, and discusses future directions for research.

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