Biomolecular condensates as stress sensors and modulators of bacterial signaling.

ABSTRACT: Microbes exhibit remarkable adaptability to environmental fluctuations. Signaling mechanisms, such as two-component systems and secondary messengers, have long been recognized as critical for sensing and responding to environmental cues. However, recent research has illuminated the potential of a physical adaptation mechanism in signaling-phase separation, which may represent a ubiquitous mechanism for compartmentalizing biochemistry within the cytoplasm in the context of bacteria that frequently lack membrane-bound organelles. This review considers the broader prospect that phase separation may play critical roles as rapid stress sensing and response mechanisms within pathogens. It is well established that weak multivalent interactions between disordered regions, coiled-coils, and other s

SUBMITTER: Sasazawa M 

PROVIDER: S-EPMC11326607 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature