Diffusion model predicts the geometry of actin cytoskeleton from cell morphology.

ABSTRACT: Cells exhibit various morphological characteristics due to their physiological activities, and changes in cell morphology are inherently accompanied by the assembly and disassembly of the actin cytoskeleton. Stress fibers are a prominent component of the actin-based intracellular structure and are highly involved in numerous physiological processes, e.g., mechanotransduction and maintenance of cell morphology. Although it is widely accepted that variations in cell morphology interact with the distribution and localization of stress fibers, it remains unclear if there are underlying geometric principles between the cell morphology and actin cytoskeleton. Here, we present a machine learning system that uses the diffusion model to convert the cell shape to the distribution and alignment of st

SUBMITTER: Li H 

PROVIDER: S-EPMC11326640 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature