Personalized Paths: Unlocking Alzheimer's via the Gut-Brain Axis.

ABSTRACT:

Background

Alzheimer's disease (AD) is characterised by abnormal protein aggregates in the brain that lead to cognitive decline. While current therapies only treat symptoms, disease-modifying treatments are urgently needed. Studies suggest that the composition of the microbiota is altered in people with AD, suggesting a link between gut bacteria and AD-related brain changes.

Summary

In our narrative review, we explore various microbial interventions, such as faecal microbiota transplantation, probiotics, and diet, as powerful potential treatments. Studies suggest changes in microbiota composition following these interventions, with some beneficial effects on cognitive function. However, the mechanism of action of these microbial interventions is still unknown.

Key message

SUBMITTER: Ceccon M 

PROVIDER: S-EPMC11326767 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature