Harnessing Endogenous Peptide Compounds as Potential Therapeutics for Severe Influenza.

ABSTRACT:

Background

Excessive pulmonary inflammation and damage are characteristic features of severe influenza virus infections. LAT8881 is a synthetic 16-amino acid cyclic peptide form of a naturally occurring C-terminal fragment of human growth hormone with therapeutic efficacy against influenza. Shorter linear peptides are typically easier to manufacture and formulate for delivery than larger cyclic peptides. A 6-amino acid linear peptide fragment of LAT8881, LAT9997, was investigated as a potential influenza therapy.

Methods

LAT9997 was evaluated for its potential to limit disease in a preclinical mouse model of severe influenza infection.

Results

Intranasal treatment of mice with either LAT8881 or LAT9997 from day 1 following influenza infection significantly improved su

SUBMITTER: West AC 

PROVIDER: S-EPMC11326819 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature