Varicella Zoster Virus Downregulates Expression of the Nonclassical Antigen Presentation Molecule CD1d.

ABSTRACT:

Background

The nonclassical antigen presentation molecule CD1d presents lipid antigens to invariant natural killer T (iNKT) cells. Activation of these cells triggers a rapid cytokine response providing an interface between innate and adaptive immune responses. The importance of CD1d and iNKT cells in varicella zoster virus (VZV) infection has been emphasized by clinical reports of individuals with CD1d or iNKT cell deficiencies experiencing severe, disseminated varicella postvaccination.

Methods

Three strains of VZV (VZV-S, rOka, and VZV rOka-66S) were used to infect Jurkat cells. Flow cytometry of VZV- and mock-infected cells assessed the modulatory impact of VZV on CD1d protein. Infected cell supernatant and transwell co-culture experiments explored the role of soluble fac

SUBMITTER: Traves R 

PROVIDER: S-EPMC11326826 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature