Antibody-Mediated Serum Resistance Protects Pseudomonas aeruginosa During Bloodstream Infections.

ABSTRACT:

Background

Pseudomonas aeruginosa is a frequent pathogen isolated from bacterial bloodstream infection (BSI) and is associated with high mortality. To survive in the blood, P aeruginosa must resist the bactericidal action of complement (ie, serum killing). Antibodies usually promote serum killing through the classical complement pathway; however, "cloaking antibodies" (cAbs) have been described, which paradoxically protect bacteria from serum killing. The relevance of cAbs in P aeruginosa BSI is unknown.

Methods

Serum and P aeruginosa were collected from a cohort of 100 patients with BSI. Isolates were tested for sensitivity to healthy control serum (HCS). cAb prevalence was determined in sera. Patient sera were mixed with HCS to determine if killing of the matched isolate w

SUBMITTER: Hickson SM 

PROVIDER: S-EPMC11326846 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature