Continuous Insulin Therapy to Prevent Post-Transplant Diabetes Mellitus: A Randomized Controlled Trial.

ABSTRACT:

Rationale & objectives

Hyperglycemia is frequently observed early after transplantation and associated with development of post-transplant diabetes mellitus (PTDM). Here, we assessed continuous subcutaneous insulin infusion (CSII) targeting afternoon hyperglycemia.

Study design

Open-label randomized parallel 3-arm design.

Settings & participants

In total, 85 kidney transplant recipients without previous diabetes diagnosis were randomized to postoperative CSII therapy, basal insulin, or control.

Interventions

Insulin was to be initiated at afternoon capillary blood glucose level of ≥140 mg/dL (7.8 mmol/L; CSII and basal insulin) or fasting plasma glucose level of ≥200 mg/dL (11.1 mmol/L; control).

Outcomes

Hemoglobin A1c (HbA1c) levels at 3 months post-tr

SUBMITTER: Kurnikowski A 

PROVIDER: S-EPMC11326904 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature