Functional magnetic resonance imaging alternations in suicide attempts individuals and their association with gene expression.

ABSTRACT:

Background

Functional Magnetic Resonance Imaging (fMRI) has shown brain activity alterations in individuals with a history of attempted suicide (SA) who are diagnosed with depression disorder (DD) or bipolar disorder (BD). However, patterns of spontaneous brain activity and their genetic correlations need further investigation.

Methods

A voxel-based meta-analysis of 19 studies including 26 datasets, involving 742 patients with a history of SA and 978 controls (both nonsuicidal patients and healthy controls) was conducted. We examined fMRI changes in SA patients and analyzed the association between these changes and gene expression profiles using data from the Allen Human Brain Atlas by partial least squares regression analysis.

Results

SA patients demonstrated increas

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC11326948 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature