IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating JAK/STAT signaling pathway.

ABSTRACT: Circular RNAs (circRNAs) represent a class of covalently closed, single-stranded RNAs and have been linked to cancer progression. N6-methyladenosine (m⁶A) methylation is a ubiquitous RNA modification in cancer cells. Increasing evidence suggests that m⁶A can mediate the effects of circRNAs in cancer biology. In contrast, the post-transcriptional systems of m⁶A and circRNA in the progression of endometrial cancer (EC) remain obscure. The current study identified a novel circRNA with m⁶A modification, hsa_circ_0084582 (circCHD7), which was upregulated in EC tissues. Functionally, circCHD7 was found to promote the proliferation of EC cells. Mechanistically, circCHD7 interacted with insulin-like growth factor 2 mRNA-binding protein (IGF2BP2) to ampli

SUBMITTER: Shi R 

PROVIDER: S-EPMC11327104 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature