Unveiling the therapeutic potential of airpotato yam rhizome against colorectal cancer: a network pharmacology approach.

ABSTRACT:

Objective

The objective of this investigation was to elucidate the key active compounds and molecular mechanisms underlying the therapeutic potential of airpotato yam rhizome (AYR) in colorectal cancer (CRC) treatment.

Methods

By utilizing network pharmacology and molecular docking, key targets and signaling pathways of AYR against CRC were predicted and subsequently validated in cellular and mouse xenograft models.

Results

This study initially predicted that quercetin was the primary compound in AYR that might have potential efficacy against CRC and that EGFR and AKT1 could be the main targets of AYR, with the EGF/EGFR-induced PI3K/AKT signaling pathway potentially playing a crucial role in the anti-CRC effects of AYR. Molecular docking analysis further indicated a s

SUBMITTER: Xie Y 

PROVIDER: S-EPMC11327141 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature