Association between gut microbiota and diabetic microvascular complications: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Gut microbiota (GM) homeostasis in the human body is closely associated with health, which can be used as a regulator for preventing the onset and progression of disease. Diabetic microvascular complications bring about not only a huge economic burden to society, but also miserable mental and physical pain. Thus, alteration of the GM may be a method to delay diabetic microvascular complications.

Objective

A two-sample Mendelian randomization (MR) analysis was conducted to reveal the causal inference between GM and three core diabetic microvascular complications, namely, diabetic kidney disease (DKD), diabetic retinopathy (DR), and diabetic neuropathy (DNP).

Methods

First, genome-wide association study (GWAS) summary statistics for GM from the MiBioGen conso

SUBMITTER: Zhou P 

PROVIDER: S-EPMC11327146 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature