Fully-automated production of [⁶⁸Ga]Ga-Trivehexin for clinical application and its biodistribution in healthy volunteers.

ABSTRACT:

Background

The α_vβ₆-integrin targeting trimeric ligand [⁶⁸Ga]Ga-Trivehexin has emerged as a promising candidate for clinical application due to its clinical imaging potentials in various malignant cancers. Our objective was to develop a simplified and reproducible module-based automated synthesis protocol to expand its availability in clinical application.

Methods

The pH value and the precursor load of radiolabeling were explored using an iQS-TS fully-automated module. Radiochemical purity was evaluated by radio-HPLC and radio-TLC. The ethanol content, radionuclide purity and identity, bacterial endotoxins, sterility, and stability of the final product [⁶⁸Ga]Ga-Trivehexin were all tested. Biodistribution of [⁶⁸Ga]Ga-Triv

SUBMITTER: Wang B 

PROVIDER: S-EPMC11327152 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature