Dual-layer spectral-detector CT for detecting liver steatosis by using proton density fat fraction as reference.

ABSTRACT:

Objectives

To evaluate the diagnostic accuracy of liver dual-layer spectral-detector CT (SDCT) derived parameters of liver parenchyma for grading steatosis with reference to magnetic resonance imaging-based proton density fat fraction (MRI-PDFF).

Methods

Altogether, 320 consecutive subjects who underwent MRI-PDFF and liver SDCT examinations were recruited and prospectively enrolled from four Chinese hospital centers. Participants were classified into normal (n = 152), mild steatosis (n = 110), and moderate/severe(mod/sev) steatosis (n = 58) groups based on MRI-PDFF. SDCT liver parameters were evaluated using conventional polychromatic CT images (CT_poly), virtual mono-energetic images at 40 keV (CT_40kev), the slope of the spectral attenuation curve (λ),

SUBMITTER: Wang M 

PROVIDER: S-EPMC11327236 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature