Vagus nerve stimulation during training fails to improve learning in healthy rats.

ABSTRACT: Learning new skills requires neuroplasticity. Vagus nerve stimulation (VNS) during sensory and motor events can increase neuroplasticity in networks related to these events and might therefore serve to facilitate learning on sensory and motor tasks. We tested if VNS could broadly improve learning on a wide variety of tasks across different skill domains in healthy, female adult rats. VNS was paired with presentation of stimuli or on successful trials during training, strategies known to facilitate plasticity and improve recovery in models of neurological disorders. VNS failed to improve either rate of learning or performance for any of the tested tasks, which included skilled forelimb motor control, speech sound discrimination, and paired-associates learning. These results contrast recent

SUBMITTER: Carroll AM 

PROVIDER: S-EPMC11327266 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature