Type 2 asthma paediatric patients eligible for dupilumab: An Italian biomarker-based analysis.

ABSTRACT:

Background

Type 2 inflammation is the principal determinant of asthma in children, and it leads to the downstream activation of eosinophils (EOS), the production of immunoglobulin-E (IgE), and increased levels of fraction of exhaled nitric oxide (FeNO). Dupilumab received the approval for the treatment of uncontrolled severe Type 2 asthma in children.

Objective

The aim of this analysis was to calculate the Type 2 severe asthma paediatric population who would be eligible for treatment with dupilumab in Italy and characterize them by expected biomarker status.

Methods

The calculation of the dupilumab-eligible population employed a two-phase approach: 1) estimating the total number of children aged 6-11 years with uncontrolled severe asthma; and 2) stratifying the severe

SUBMITTER: Piacentini G 

PROVIDER: S-EPMC11327463 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature