The association between cytomegalovirus infection and neurodegenerative diseases: a prospective cohort using UK Biobank data.

ABSTRACT:

Background

Certain viral infections have been linked to the development of neurodegenerative diseases. This study aimed to investigate the association between cytomegalovirus (CMV) infection and five neurodegenerative diseases, spinal muscular atrophy (SMA) and related syndromes, Parkinson's disease (PD), Alzheimer's disease (AD), multiple sclerosis (MS), and disorders of the autonomic nervous system (DANS).

Methods

This prospective cohort included white British individuals who underwent CMV testing in the UK Biobank from January 1, 2006 to December 31, 2021. A Cox proportional hazard model was utilized to estimate the future risk of developing five neurodegenerative diseases in individuals with or without CMV infection, adjusted for batch effect, age, sex, and Townsend depr

SUBMITTER: Ma X 

PROVIDER: S-EPMC11327475 | biostudies-literature | 2024 Aug

REPOSITORIES: biostudies-literature